ubiquitin c การใช้

• TTC39B interacts with ubiquitin C ( UBC ), a polyubiquitin precursor.
• KOR has been shown to interact with sodium-hydrogen antiporter 3 regulator 1 and ubiquitin C.
• The function of TTC35 is unknown but it is also known to interact with Cox4NB and Ubiquitin C.
• This domain is found as a single copy in other proteins, including phosphatases and ubiquitin C-terminal hydrolases.
• Canonical ubiquitylation creates an isopeptide bond between a lysine residue on a target protein and the ubiquitin C-terminal Glycine 76.
• NDUFA4 has many protein-protein interactions, including ubiquitin proteins such as ubiquitin C and UBL4A, as well as CUL3 and PARK7.
• Using this method, ACAD10 has been shown to interact with P2RY8, NDUFA10, NTRK3, SLC2A12, LPAR4, PTH1R, COLEC10, BSG, and Ubiquitin C.
• DUBs are categorised into 5 main groups, ubiquitin-specific proteases ( USP ), ubiquitin c-terminal hydrolases ( UCH ), ovarian tumour proteases ( OTU ), Machado-Joseph disease proteases ( MJD ), and JAB1 / MPN / MOV34 proteases ( JAMM / MPN + ).
• In humans there are 102 putative DUB genes, which can be classified into two main classes : cysteine proteases and metalloproteases, consisting of 58 ubiquitin-specific proteases ( USPs ), 4 ubiquitin C-terminal hydrolases ( UCHs ), 5 Machado-Josephin domain proteases ( MJDs ), 14 ovarian tumour proteases ( OTU ), and 14 Jab1 / Mov34 / Mpr1 Pad1 N-terminal + ( MPN + ) ( JAMM ) domain-containing genes . 11 of these proteins are predicted to be non-functional, leaving 79 functional enzymes.
• It ( they ) regulates signaling by : "'a ) "'inhibiting the STAT3-Janus kinase pathway to block cellular pro-inflammatory responses; "'b ) "'stimulating Suppressor of cytokine signaling 1, Suppressor of cytokine signaling 3, and Src homology 2 domain-containg protein phosphatase 2 pathways to inhibit the actions of pro-inflammatory cytokines; "'c ) "'inhibiting the activation of ERK1, ERK2, Akt and a p38 mitogen-activated protein kinases pathways to inhibit the actions of pro-inflammatory cytokines and / or the differentiation of progenitor cells to pro-inflammatory Dendritic cells; "'d ) "'regulating the cell cycle and cell proliferation by stimulating p21, cFos, Erg-1, and cMyc or inhibiting N-Myc, Cyclin D1, Cdk4, and Insulin-like growth factor 1; and "'e ) "'regulating agents such as HSP70, GPR78, Gadd153, Ubiquitin B, and Ubiquitin C which contribute to the degradation of abnormal proteins.